Adverse Effects of Treatment

  • Abstract
  • Diagnosis
  • Treatment Options and Methods
  • Adverse Effects of Treatment
  • Selection of Treatment
  • Special Management Issues
  • References

The side effects of each treatment method and the risk of recurrence are summarized in Table 3 .8 – 13 All of these treatment methods can cause considerable discomfort, erythema, epithelial erosion, ulceration at the treatment site, depigmentation, and scarring. Treatment should be confined to affected skin to minimize the risk of side effects. Little objective information has been published regarding the management of complications of therapy for genital warts; the use of non-prescription analgesics is a reasonable option to alleviate discomfort.

Patient counseling and education can help prepare patients for possible adverse effects and ensure that they have appropriate expectations. Safely buy aldara cream online, but patients must understand that HPV infections can be treated but not cured; that affected men and women, and sex partners of affected patients, are at risk for cervical or genital cancer; and that affected women and female sex partners of affected men should have regular Pap smears performed.

Patients Being Treated for Superficial Basal Cell Carcinoma (sBCC)

  1. It is recommended that the treatment area be washed with mild soap and water 8 hours following Aldara Cream application.
  2. Most patients using Aldara Cream for the treatment of sBCC experience erythema, edema, induration, erosion, scabbing/crusting and flaking/scaling at the application site with normal dosing. These local skin reactions generally decrease in intensity or resolve after cessation of Aldara Cream therapy. Patients may also experience application site reactions such as itching and/or burning. Local skin reactions may be of such an intensity that patients may require rest periods from treatment. Treatment with Aldara Cream can be resumed after the skin reaction has subsided, as determined by the physician.
  3. During treatment and until healed, affected skin is likely to appear noticeably different from normal skin.
  4. It is prudent for patients to minimize or avoid exposure to natural or artificial sunlight.
  5. The clinical outcome of therapy can be determined after regeneration of the treated skin, approximately 12 weeks after the end of treatment.
  6. Patients should contact their physician if they experience any sign or symptom at the application site that restricts or prohibits their daily activity or makes continued application of the cream difficult.
  7. Patients with sBCC treated with Aldara Cream are recommended to have regular follow-up to re-evaluate the treatment site.

Pharmacokinetics

Systemic absorption of imiquimod was observed across the affected skin of 12 patients with genital/perianal warts, with an average dose of 4.6 mg. Mean peak drug concentration of approximately 0.4 ng/mL was seen during the study. Mean urinary recoveries of imiquimod and metabolites combined over the whole course of treatment, expressed as percent of the estimated applied dose, were 0.11 and 2.41% in the males and females, respectively.

Systemic absorption of imiquimod across the affected skin of 58 patients with AK was observed with a dosing frequency of 3 applications per week for 16 weeks. Mean peak serum drug concentrations at the end of week 16 were approximately 0.1, 0.2, and 3.5 ng/mL for the applications to face (12.5 mg imiquimod, 1 single-use packet), scalp (25 mg, 2 packets) and hands/arms (75 mg, 6 packets), respectively.

The application surface area was not controlled when more than one packet was used. Dose proportionality was not observed. However it appears that systemic exposure may be more dependent on surface area of application than amount of applied dose. The apparent half-life was approximately 10 times greater with topical dosing than the 2 hour apparent half-life seen following subcutaneous dosing, suggesting prolonged retention of drug in the skin. Mean urinary recoveries of imiquimod and metabolites combined were 0.08 and 0.15% of the applied dose in the group using 75 mg (6 packets) for males and females, respectively following 3 applications per week for 16 weeks.

What do I need to tell my doctor BEFORE I take Aldara?

  • If you are allergic to Aldara (imiquimod cream (aldara)); any part of Aldara (imiquimod cream (aldara)); or any other drugs, foods, or substances. http://www.goodrx.com/imiquimod/side-effects Tell your doctor about the allergy and what signs you had.
  • If your skin has not healed from other care or surgery.
  • If you are using another drug that has the same drug in it.

This is not a list of all drugs or health problems that interact with Aldara (imiquimod cream (aldara)).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Aldara (imiquimod cream (aldara)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

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